Article
The association of OGG1 Ser326Cys polymorphism and urinary 8-OHdG levels with lung cancer susceptibility: a hospital-based case-control study in Turkey.
Arhiv za higijenu rada i toksikologiju - 1 Dec 2008
Karahalil Bensu, Emerce Esra, Koçer Bülent, Han Serdar, Alkiş Necati, Karakaya Ali Esat
Abstract excerpt
High incidence and poor prognosis of lung cancer make it a major health problem worldwide. Although smoking is a major cause of lung cancer, only some smokers develop lung cancer, which suggests that there is a genetic predisposition in some individuals. 8-OHG is an important oxidative base lesion and may elevate due to cancer and smoking. It is repaired by 8-hydroxyguanine DNA glycosylase 1 (OGG1), which has...
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