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Article

Initial characterization of autoprocessing and active-center mutants of CMV proteinase.

Journal of protein chemistry - 1 Nov 1996

Snyder S W, Edalji R P, Lindh F G, Walter K A, Solomon L, Pratt S, Steffy K, Holzman T F

Abstract excerpt

Human cytomegalovirus (CMV) encodes a unique serine proteinase that is required in the maturation of the viral capsid. The CMV proteinase can undergo autocatalytic activation and is subject to proteolytic self-inactivation. Mutant enzyme forms were prepared to eliminate the initial autoprocessing site and thus form an active single-chain protein for structure-function studies. Two mutants of CMV proteinase were...

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PMID: 9008301
DOI: 10.1007/BF01887151

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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