Article
The imprinted Igf2-Igf2r axis is critical for matching placental microvasculature expansion to fetal growth
27 Dec 2021
Abstract excerpt
In all eutherian mammals, growth of the fetus is dependent upon a functional placenta, but whether and how the latter adapts to putative fetal signals is currently unknown. Here, we demonstrate, through fetal, endothelial, hematopoietic, and trophoblast-specific genetic manipulations in the mouse, that endothelial and fetus-derived IGF2 is required for the continuous expansion of the feto-placental...
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