Article
Placental phenotypes of intrauterine growth.
Pediatric research - 1 Nov 2005
Sibley Colin P, Turner Mark A, Cetin Irene, Ayuk Paul, Boyd C A Richard, D'Souza Stephen W, Glazier Jocelyn D, Greenwood Susan L, Jansson Thomas, Powell Theresa
Abstract excerpt
The placenta is essential to nutrition before birth. Recent work has shown that a range of clearly defined alterations can be found in the placentas of infants with intrauterine growth restriction (IUGR). In the mouse, a placental specific knockout of a single imprinted gene, encoding IGF-2, results in one pattern of alterations in placenta structure and function which leads to IUGR. We speculate that the...
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