Article
IL-1beta gene polymorphisms influence hepatitis B vaccination.
Vaccine - 19 Aug 2002
Yucesoy Berran, Sleijffers Annemarie, Kashon Michael, Garssen Johan, de Gruijl Frank R, Boland Greet J, van Hattum Jan, Simeonova Petia P, Luster Michael I, van Loveren Henk
Abstract excerpt
Considerable variability exists in the vaccine response to hepatitis B with 5-10% of healthy young adults demonstrating no or inadequate responses following a standard vaccination schedule. As the interleukin-1beta (IL-1beta) cytokine has been shown to be important in the development of immune responses, we determined whether vaccine efficacy is influenced by genetic polymorphisms associated with IL-1beta...
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