Article
Human leukocyte antigens influence the immune response to a pre-S/S hepatitis B vaccine.
Vaccine - 28 Jan 1999
McDermott A B, Cohen S B, Zuckerman J N, Madrigal J A
Abstract excerpt
In this study we investigated the effects of a single pre-S/S (Hepagene) revaccination in a large population of multiple 'S' vaccinated anti-HBs antibody nonresponder individuals (< 3 IU/l). We investigate the influence of vaccine dose (5, 10, 20 and 40 micrograms/ml), number of previous 'S' containing vaccinations and the individuals HLA genotype on both B- and T-cell responses. We show that 76% of persistently...
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