Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Eight-plasmid system for rapid generation of influenza virus vaccines.

Vaccine - 19 Aug 2002

Hoffmann Erich, Krauss Scott, Perez Daniel, Webby Richard, Webster Robert G

Abstract excerpt

The antigenic variation of influenza A virus hemagglutinin (HA) and neuraminidase (NA) glycoproteins requires frequent changes in vaccine formulation. The classical method of creating influenza virus seed strains for vaccine production is to generate 6 + 2 reassortants that contain six genes from a high-yield virus, such as A/PR/8/34 (H1N1) and the HA and NA genes of the circulating strains. The techniques...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigenic Variation
Share to Chick Embryo
Share to DNA, Recombinant

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Influenza A virus

Share to Influenza Vaccines

Share to Panama

Share to Reassortant Viruses

Share to Virus Cultivation

Source

Identifiers

PMID: 12163268
DOI: 10.1016/s0264-410x(02)00268-2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Eight-plasmid system for rapid generation of influenza virus vaccines.PMID 12163268Read ↗

An improved reverse genetics system for influenza A virus generation and its implications for vaccine productionSemantic proximity Read ↗

Evaluation of a Genetically Modified Reassortant H5N1 Influenza A Virus Vaccine Candidate Generated by Plasmid-Based Reverse GeneticsSemantic proximity Read ↗

Single PA mutation as a high yield determinant of avian influenza vaccines.Semantic proximity Read ↗

Development of high-yield influenza A virus vaccine viruses.Semantic proximity Read ↗

Development of an Influenza A Master Virus for Generating High-Growth Reassortants for A/Anhui/1/2013(H7N9) Vaccine Production in Qualified MDCK Cells.Semantic proximity Read ↗

Engineering influenza viral vectorsSemantic proximity Read ↗

Development of a high-yield reassortant influenza vaccine virus derived from the A/Anhui/1/2013 (H7N9) strainSemantic proximity Read ↗

Reverse Genetics Approaches for the Development of Influenza VaccinesSemantic proximity Read ↗

A Vero-cell-adapted vaccine donor strain of influenza A virus generated by serial passages.Semantic proximity Read ↗

Development of a new candidate H5N1 avian influenza virus for pre‐pandemic vaccine productionSemantic proximity Read ↗

Generation of influenza virus from avian cells infected by Salmonella carrying the viral genome.Semantic proximity Read ↗

Generation of influenza A viruses entirely from cloned cDNAsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.