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Article

Angiotensin-converting enzyme (ACE and ACE2) imbalance correlates with the severity of cerulein-induced acute pancreatitis in mice.

Experimental physiology - 1 Apr 2014

Liu Ruixia, Qi Haiyu, Wang Jing, Wang Yan, Cui Lijian, Wen Yan, Yin Chenghong

Abstract excerpt

Angiotensin-converting enzyme (ACE) and its effector peptide angiotensin II (Ang II) have been implicated in the pathogenesis of pancreatitis. Angiotensin-converting enzyme 2 (ACE2) degrades Ang II to angiotensin-(1-7) [Ang-(1-7)] and has recently been described to have an antagonistic effect on ACE signalling. However, the specific underlying role of ACE2 in the pathogenesis of severe acute pancreatitis (SAP) is...

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Source

Identifiers

PMID: 24414175
DOI: 10.1113/expphysiol.2013.074815

Genes

ACE2
ACE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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