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1364. Adenoviral Gene Therapy for Renal Cancer Requires Retargeting to Alternative Cellular Receptors

1 May 2002

Abstract excerpt

Metastatic renal cell carcinoma (RCC) is one of the most treatment-resistant malignancies in humans. Therefore, the identification of new agents with better antitumor activity merits a high priority in the treatment of advanced RCC. In this regard, gene therapy with adenoviral (Ad) vectors is a promising new modality for cancer. However, a primary limiting factor for the use of Ad vectors for cancer gene therapy...

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PMID: 12154029
DOI: 10.1016/s1525-0016(16)44194-8

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