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Article

Mechanisms of resistance to antiretroviral drugs--clinical implications.

AIDS reviews - 1 Jan 2000

de Mendoza Carmen, Gallego Oscar, Soriano Vincent

Abstract excerpt

HIV resistance to antiretroviral agents involves the selection of mutations within the reverse transcriptase (RT) and protease (PRO) genes, that result in structural changes causing in most instances a loss of affinity of RT and PRO inhibitors for their respective targets. Then, the inhibitory competition caused by these molecules in respect to the physiologic substrates of the RT and PRO enzymes is lost. For...

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PMID: 12152520

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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