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Article

Genetic mechanisms of resistance to NRTI and NNRTI.

HIV clinical trials - 1 Jan 2000

Soriano Vincent, de Mendoza Carmen

Abstract excerpt

Resistance to nucleoside reverse transcriptase inhibitors (NRTIs) seems to develop following three different pathways. Discriminatory mutations favor the binding of physiologic nucleosides over that of drugs. The newly so-called nucleoside-associated mutations (NAMs) enhance the removal of chain terminators (pyrophosphorolysis) from the cDNA in formation. Finally, some inserts at the p6 region within the gag gene...

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Source

Identifiers

PMID: 12032883
DOI: 10.1310/hct.2002.3.3.008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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