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Article

Mutational patterns in the HIV genome and cross-resistance following nucleoside and nucleotide analogue drug exposure.

Antiviral therapy - 1 Jan 2001

Miller V, Larder B A

Abstract excerpt

A variety of key mutations in HIV reverse transcriptase (RT) have been associated with nucleoside reverse transcriptase inhibitor (NRTI) exposure, which give rise to a diverse range of effects in terms of altered drug susceptibilities, viral replicative capacity and RT biochemistry. There are three basic mechanisms of resistance conferred by specific mutations in the coding region of RT. The first is drug...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 11678471

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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