Mechanisms of anti-retroviral drug resistance: implications for novel drug discovery and development.

Abstract excerpt

Anti-retroviral drug resistance evolves as an inevitable consequence of expanded combination Anti-retroviral Therapy (cART). According to each drug class, resistance mutations may occur due to the infidel nature of HIV reverse transcriptase (RT) and inadequate drug pressures. Correspondingly, resistance to Nucleoside Reverse Transcriptase Inhibitors (NRTIs) occurs due to incorporation impairment of the agent or...

Topics

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• Amino Acid Substitution
• Anti-HIV Agents
• Drug Design
• Drug Discovery
• Drug Resistance, Viral