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Article

Cleavage of caspase-12 at Asp94, mediated by endoplasmic reticulum stress (ERS), contributes to stretch-induced apoptosis of myoblasts.

Journal of cellular physiology - 1 Dec 2018

Song Jing, Zhang Qiang, Wang Shuai, Yang Fang, Chen Zhenggang, Dong Quanjiang, Ji Qiuxia, Yuan Xiao, Ren Dapeng

Abstract excerpt

Mechanical overloading can lead to skeletal muscle damage instead of remodeling. This is attributed to the excessive apoptosis of myoblasts, mechanism of which remains to be elucidated. The present study aimed to investigate the involvement of endoplasmic reticulum stress (ERS) and caspase-12 in mediating the stretch-induced apoptosis of myoblasts. Myoblast apoptosis was evaluated by Hoechst staining, DNA...

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Identifiers

PMID: 29943814
DOI: 10.1002/jcp.26840

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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