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Article

Use of denaturing HPLC to map human and murine genes and to validate single-nucleotide polymorphisms.

BioTechniques - 1 Apr 2000

Schriml L M, Peterson R J, Gerrard B, Dean M

Abstract excerpt

Linkage mapping has been extensively applied in the murine and human genomes. It remains a powerful approach to mapping genes and identifying genetic variants. As genome efforts identify large numbers of single-nucleotide polymorphisms, it will be critical to validate these polymorphisms and confirm their gene assignment and chromosomal location. The presence of pseudogenes can confuse such efforts. We have used...

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PMID: 10769753
DOI: 10.2144/00284rr03

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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