Article
Amplification of cyclin D1 in squamous cell carcinoma of the head and neck and the prognostic value of chromosomal abnormalities and cyclin D1 overexpression.
Cancer - 15 Jan 1997
Akervall J A, Michalides R J, Mineta H, Balm A, Borg A, Dictor M R, Jin Y, Loftus B, Mertens F, Wennerberg J P
Abstract excerpt
BACKGROUND: Abnormalities of chromosome band 11q13 are frequent in squamous cell carcinoma of the head and neck (SCCHN). The oncogene CCND1 is located at 11q13 and encodes cyclin D1, a cell cycle-regulating protein. The authors investigated the clinical relevance and associations between amplific...
Topics
- Adult
- Aged
- Aged, 80 and over
- Carcinoma, Squamous Cell
- Chromosome Aberrations
- Chromosomes, Human, Pair 11
- Cyclin D1
- Cyclins
- Female
- Gene Amplification
- Gene Rearrangement
- Head and Neck Neoplasms
- Humans
- Male
- Middle Aged