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Article

Amplification of cyclin D1 in squamous cell carcinoma of the head and neck and the prognostic value of chromosomal abnormalities and cyclin D1 overexpression.

Cancer - 15 Jan 1997

Akervall J A, Michalides R J, Mineta H, Balm A, Borg A, Dictor M R, Jin Y, Loftus B, Mertens F, Wennerberg J P

Abstract excerpt

BACKGROUND: Abnormalities of chromosome band 11q13 are frequent in squamous cell carcinoma of the head and neck (SCCHN). The oncogene CCND1 is located at 11q13 and encodes cyclin D1, a cell cycle-regulating protein. The authors investigated the clinical relevance and associations between amplification and overexpression of cyclin D1 and 11q13 rearrangements. METHODS: The study involved two series of patients. In...

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Source

Identifiers

PMID: 9010112

Genes

CCND1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Amplification of cyclin D1 in squamous cell carcinoma of the head and neck and the prognostic value of chromosomal abnormalities and cyclin D1 overexpression.PMID 9010112Read ↗

Chromosome 11q13 Amplification in Head and Neck Squamous Cell Carcinoma: Association With Poor PrognosisSemantic proximity Read ↗

Chromosome 11Q13 Amplification in Head and Neck Squamous Cell CarcinomaSemantic proximity Read ↗

Array-Based Comparative Genomic Hybridization Analysis Identified Cyclin D1 as a Target Oncogene at 11q13.3 in Nasopharyngeal CarcinomaSemantic proximity Read ↗

Amplification of chromosome band 11q13 and a role for cyclin D1 in human breast cancerSemantic proximity Read ↗

Cyclin D1 Amplification and p16(MTS1/CDK4I) Deletion Correlate With Poor Prognosis in Head and Neck TumorsSemantic proximity Read ↗

Amplification and overexpression of cyclin D1 in breast cancer detected by immunohistochemical staining.Semantic proximity Read ↗

Prognostic significance of cyclin D1 protein expression and gene amplification in invasive breast carcinomaSemantic proximity Read ↗

An update on the implications of cyclin D1 in oral carcinogenesisSemantic proximity Read ↗

Cyclin-D1-gene amplification is a more potent prognostic factor than its protein over-expression in human head-and-neck squamous-cell carcinomaSemantic proximity Read ↗

Gene products of chromosome 11q and their association with CCND1gene amplification and tamoxifen resistance in premenopausal breast cancerSemantic proximity Read ↗

Cortactin expression predicts poor survival in laryngeal carcinomaSemantic proximity Read ↗

Association between CCND1 G/A870 polymorphism, allele-specific amplification, cyclin D1 expression, and survival in esophageal and lung carcinoma.Semantic proximity Read ↗

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