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Article

Clinical correlates of promoter hypermethylation of four target genes in head and neck cancer: a cooperative group correlative study.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 May 2013

Roh Jong-Lyel, Wang Xin Victoria, Manola Judith, Sidransky David, Forastiere Arlene A, Koch Wayne M

Abstract excerpt

PURPOSE: Promoter hypermethylation is a well-documented mechanism for tumor-specific alteration of suppressor gene activity in human malignancy including head and neck cancer (HNC). The abrogation of specific suppressor gene activity may influence tumor behavior and clinical outcome. In this study we examined methylation of DCC, KIF1A, EDNRB, and p16(INK4a) in a large cohort of HNC patients from Eastern...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23444219
DOI: 10.1158/1078-0432.CCR-12-3047
PMCID: PMC3642232

Genes

DCC
EDNRB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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