Article
The association between glutathione S-transferase P1 genotype and plasma level in head and neck cancer.
The Laryngoscope - 1 Mar 2002
Kelders Willem P A, Oude Ophuis Michael B, Roelofs Hennie M J, Peters Wilbert H M, Manni Johannes J
Abstract excerpt
OBJECTIVES/HYPOTHESIS: Glutathione S-transferase P1-1 (GSTP1-1) is an important enzyme because it plays a major role in many detoxification reactions, including tobacco-related metabolic products. GSTP1-1 is the most abundant of all glutathione S-transferase (GST) enzymes in normal human head and neck epithelium, whereas it is overexpressed in head and neck malignancies. At least three different GSTP1 genotypes...
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