Article
Novel mutations and sequence variants in exons 3-9 of human T cell factor-4 gene in sporadic rectal cancer patients stratified by microsatellite instability.
World journal of gastroenterology - 21 Jul 2007
Meng Wen-Jian, Wang Ling, Tian Chao, Yu Yong-Yang, Zhou Bing, Gu Jun, Xia Qing-Jie, Sun Xiao-Feng, Li Yuan, Wang Rong, Zheng Xue-Lian, Zhou Zong-Guang
Abstract excerpt
AIM: To establish the role of human T Cell Factor-4 (hTCF-4) gene exons 3-9 mutation status in association with sporadic rectal cancer with microsatellite instability (MSI). METHODS: Microsatellite markers were genotyped in 93 sporadic rectal cancer patients. Eleven cases were found to be high-frequency MSI (MSI-H). Sequence analysis of the coding region of the exons 3-9 of hTCF-4 gene was carried out for the 11...
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