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Article

The Pro115Gln polymorphism within the PPAR gamma2 gene has no epidemiological impact on morbid obesity.

Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association - 1 Aug 2002

Hamer O W, Forstner D, Ottinger I, Ristow M, Bollheimer L C, Schölmerich J, Palitzsch K D

Abstract excerpt

The peroxisome-proliferator-activated receptor gamma2 (PPAR gamma2) is a transcriptional key regulator of adipocyte differentiation. PPAR gamma2 can be inactivated by phosphorylation of a serine residue at position 114. A point mutation leading to an amino acid exchange at position 115 (Pro115Gln) was shown to preclude serine phosphorylation and to consecutively accelerate adipocyte differentiation emphasizing...

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Identifiers

PMID: 12148087
DOI: 10.1055/s-2002-33072

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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The Pro115Gln polymorphism within the PPAR gamma2 gene has no epidemiological impact on morbid obesity.PMID 12148087Read ↗

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Variation in the gene for human peroxisome proliferator activated receptor gamma (PPARgamma) does not play a major role in the development of morbid obesity.Semantic proximity Read ↗

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