Article
The Pro115Gln and Pro12Ala PPAR gamma gene mutations in obesity and type 2 diabetes.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity - 1 Mar 2000
Clement K, Hercberg S, Passinge B, Galan P, Varroud-Vial M, Shuldiner A R, Beamer B A, Charpentier G, Guy-Grand B, Froguel P, Vaisse C
Abstract excerpt
OBJECTIVE: Peroxisome-proliferator-activated receptors gamma (PPAR gamma), is a key regulator of adipocyte differentiation and energy balance. Two naturally occurring mutations in the PPAR gamma gene, Pro115Gln and Pro12Ala, have recently been shown to impair the function of the PPAR gamma2 isoform of the receptor and to be associated with obesity or diabetes-related phenotypes in different populations. SUBJECTS:...
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