Article
Obesity associated with a mutation in a genetic regulator of adipocyte differentiation.
The New England journal of medicine - 1 Oct 1998
Ristow M, Müller-Wieland D, Pfeiffer A, Krone W, Kahn C R
Abstract excerpt
BACKGROUND: There is increasing evidence of genetic factors leading to obesity, but the exact genes involved have not been defined. Peroxisome-proliferator-activated receptor gamma2 (PPARgamma2) is a transcription factor that has a key role in adipocyte differentiation, and therefore mutations of...
Topics
- Adipocytes
- Animals
- Base Sequence
- Cell Differentiation
- Cell Line
- DNA Mutational Analysis
- Female
- Fibroblasts
- Gene Expression Regulation
- Humans
- Male
- Mice
- Middle Aged
- Mutation
- Obesity
- Phosphorylation
- Receptors, Cytoplasmic and Nuclear
- Serine