Article
Obesity associated with a mutation in a genetic regulator of adipocyte differentiation.
The New England journal of medicine - 1 Oct 1998
Ristow M, Müller-Wieland D, Pfeiffer A, Krone W, Kahn C R
Abstract excerpt
BACKGROUND: There is increasing evidence of genetic factors leading to obesity, but the exact genes involved have not been defined. Peroxisome-proliferator-activated receptor gamma2 (PPARgamma2) is a transcription factor that has a key role in adipocyte differentiation, and therefore mutations of the gene for this factor might predispose people to obesity. METHODS: We studied 358 unrelated German subjects,...
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