Article
Detection of anatoxin-a(s) in environmental samples of cyanobacteria by using a biosensor with engineered acetylcholinesterases.
Applied and environmental microbiology - 1 Aug 2002
Devic Eric, Li Dunhai, Dauta Alain, Henriksen Peter, Codd Geoffrey A, Marty Jean-Louis, Fournier Didier
Abstract excerpt
Bioassays are little used to detect individual toxins in the environment because, compared to analytical methods, these assays are still limited by several problems, such as the sensitivity and specificity of detection. We tentatively solved these two drawbacks for detection of anatoxin-a(s) by engineering an acetylcholinesterase to increase its sensitivity and by using a combination of mutants to obtain...
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