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Article

Highly sensitive detection and discrimination of LR and YR microcystins based on protein phosphatases and an artificial neural network.

Analytical and bioanalytical chemistry - 1 Aug 2012

Covaci O I, Sassolas A, Alonso G A, Muñoz R, Radu G L, Bucur B, Marty J-L

Abstract excerpt

The inhibition characteristics of three different protein phosphatases by three microcystin (MC) variants--LR, YR, and RR--were studied. The corresponding K (I) for each enzyme-MC couple was calculated. The toxicity of MC varies in the following order: MC-LR > MC-YR > MC-RR. The sensitivity of the enzymes increased in the following order: mutant PP2A < mutant PP1 < natural PP2A. The best limit of detection...

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PMID: 22648166
DOI: 10.1007/s00216-012-6092-6

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