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Article

Screening assays for cholinesterases resistant to inhibition by organophosphorus toxicants.

Analytical biochemistry - 1 Jun 2004

Wang Yuxia, Schopfer Lawrence M, Duysen Ellen G, Nachon Florian, Masson Patrick, Lockridge Oksana

Abstract excerpt

Methods to measure resistance to inhibition by organophosphorus toxicants (OP) for mutants of butyrylcholinesterase (EC 3.1.1.8; BChE) and acetylcholinesterase (EC 3.1.1.7; AChE) enzymes were devised. Wild-type cholinesterases were completely inhibited by 0.1 mM echothiophate or 0.001 mM diisopropylfluorophosphate, but human BChE mutants G117H, G117D, L286H, and W231H and snake AChE mutant HFQT retained activity....

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Identifiers

PMID: 15136175
DOI: 10.1016/j.ab.2004.02.038

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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