Article
Visualizing human leukocyte antigen class II risk haplotypes in human systemic lupus erythematosus.
American journal of human genetics - 1 Sept 2002
Graham Robert R, Ortmann Ward A, Langefeld Carl D, Jawaheer Damini, Selby Scott A, Rodine Peter R, Baechler Emily C, Rohlf Kristine E, Shark Katherine B, Espe Karl J, Green Linda E, Nair Rajan P, Stuart Philip E, Elder James T, King Richard A, Moser Kathy L, Gaffney Patrick M, Bugawan Teodorica L, Erlich Henry A, Rich Stephen S, Gregersen Peter K, Behrens Timothy W
Abstract excerpt
Human leukocyte antigen (HLA) class I and class II alleles are implicated as genetic risk factors for many autoimmune diseases. However, the role of the HLA loci in human systemic lupus erythematosus (SLE) remains unclear. Using a dense map of polymorphic microsatellites across the HLA region in a large collection of families with SLE, we identified three distinct haplotypes that encompassed the class II region...
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