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Article

Irisin protects against endothelial injury and ameliorates atherosclerosis in apolipoprotein E-Null diabetic mice.

Atherosclerosis - 1 Dec 2015

Lu Junyan, Xiang Guangda, Liu Min, Mei Wen, Xiang Lin, Dong Jing

Abstract excerpt

OBJECTIVE: The circulating irisin increases energy expenditure and improves insulin resistance in mice and humans. The improvement of insulin resistance ameliorates atherosclerosis. Therefore, we hypothesized that irisin alleviates atherosclerosis in diabetes. METHODS: Endothelial function was measured by acetylcholine-induced endothelium-dependent vasodilation using aortic rings in apolipoprotein E-Null...

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Identifiers

PMID: 26520898
DOI: 10.1016/j.atherosclerosis.2015.10.020

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