Article

The effects of experimental hyperglycaemia and hyperinsulinaemia on macrovascular endothelial cell function

2019-01-01

Abstract excerpt

Endothelial dysfunction, characterised by decreased NO synthesis, is associated with an increased risk of cardiovascular complications in patients with type 1 diabetes mellitus, type 2 diabetes mellitus (T2DM) and insulin resistance. The dysfunctional endothelium exhibits impaired insulin-stimulated NO generation and vasodilatation, as well as increased pro-inflammatory and pro-atherogenic signalling, which promot...

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Literature Corpus work: 9fe07f52-1e9b-54fe-96d9-ae5b7b57d3a9
DOI: 10.5525/gla.thesis.40910

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