Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

[Genetic differences in enzymes of folic acid metabolism in patients with lip-jaw-palate clefts and their relatives].

Mund-, Kiefer- und Gesichtschirurgie : MKG - 1 May 2002

Grunert R R, Braune A, Schnackenberg E, Schloot W, Krause H R

Abstract excerpt

BACKGROUND: The effectiveness of folic acid supplementation in the periconceptional period for the prevention of cleft lip/cleft lip and palate (CLP) is contradictorily discussed. Genetically determined variants of enzymes of the folic acid metabolism could be part of the key to success or failure of folate supplementation. A mutation of the methylenetetrahydrofolate reductase (MTHFR) gene is suspected to be a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Arylamine N-Acetyltransferase
Share to Cleft Lip

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cleft Palate

Share to Folic Acid

Share to Methylenetetrahydrofolate Reductase (NADPH2)

Share to Oxidoreductases Acting on CH-NH Group Donors

Share to Reference Values

Source

Identifiers

PMID: 12143122
DOI: 10.1007/s10006-001-0361-4

Genes

MTHFR
NAT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

[Genetic differences in enzymes of folic acid metabolism in patients with lip-jaw-palate clefts and their relatives].PMID 12143122Read ↗

C677T variant form at the MTHFR gene and CL/P: a risk factor for mothers?Semantic proximity Read ↗

Maternal MTR genotype contributes to the risk of non-syndromic cleft lip and palate in the Polish population.Semantic proximity Read ↗

Relationship between reduced folate carrier gene polymorphism and non-syndromic cleft lip and palate in Indian population.Semantic proximity Read ↗

[Study on the association between reduced folate carrier gene polymorphism and congenital heart defects and cleft lip with or without cleft palate].Semantic proximity Read ↗

Associations of folate and choline metabolism gene polymorphisms with orofacial clefts.Semantic proximity Read ↗

Polymorphisms in genes MTHFR, MTR and MTRR are not risk factors for cleft lip/palate in South BrazilSemantic proximity Read ↗

Folate-related gene polymorphisms as risk factors for cleft lip and cleft palate.Semantic proximity Read ↗

Significant association of MTHFD1 1958G>A single nucleotide polymorphism with nonsyndromic cleft lip and palate in Indian population.Semantic proximity Read ↗

Maternal polymorphisms in folic acid metabolic genes are associated with nonsyndromic cleft lip and/or palate in the Brazilian population.Semantic proximity Read ↗

Non-syndromic cleft palate: Association analysis on three gene polymorphisms of the folate pathway in Asian and Italian populations.Semantic proximity Read ↗

MTHFR C677T and A1298C polymorphisms and risk of nonsyndromic orofacial clefts in a south Indian population.Semantic proximity Read ↗

[Association study for gene polymorphism of folic acid/homocysteine metabolic pathway and nonsyndromic cleft lip with or without cleft palate in Chinese populations].Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.