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Molecular cloning of Chinese hamster ceramide glucosyltransferase and its enhanced expression in peroxisome-defective mutant Z65 cells.

Archives of biochemistry and biophysics - 15 Jul 2002

Saito Makiko, Fukushima Yasushi, Tatsumi Ken, Bei Lin, Fujiki Yukio, Iwamori Masao, Igarashi Takashi, Sakakihara Yoichi

Abstract excerpt

To clarify the metabolic bases of characteristic increases in the concentrations of glucosylceramide (CMH) and GM3 in peroxisome-defective mutant Chinese hamster ovary (CHO) cells (Z65), we measured the ceramide glucosyltransferase (CGT) and beta-glucosidase activities in Z65 and CHO-K1 cells, and found that the former enzyme was responsible for the accumulation of CMH in Z65 cells. Inhibition of CGT by...

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PMID: 12139966
DOI: 10.1016/s0003-9861(02)00216-3

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