Article
Molecular cloning and functional expression of human acyl-coenzyme A:cholesterol acyltransferase cDNA in mutant Chinese hamster ovary cells.
The Journal of biological chemistry - 5 Oct 1993
Chang C C, Huh H Y, Cadigan K M, Chang T Y
Abstract excerpt
Accumulation of cholesterol esters as cytoplasmic lipid droplets within macrophages and smooth muscle cells is a characteristic feature of early lesions of atherosclerotic plaque. Intracellularly, an essential element in forming cholesterol ester from cholesterol is the enzyme acyl-coenzyme A:cho...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- CHO Cells
- Cells, Cultured
- Cloning, Molecular
- Cricetinae
- DNA, Complementary
- Genes
- Humans
- Molecular Sequence Data
- Mutation
- Open Reading Frames
- RNA, Messenger
- Sequence Analysis, DNA
- Sterol O-Acyltransferase