Article
Toward positional cloning with SNPs.
Current opinion in molecular therapeutics - 1 Jun 2002
Morton Newton E, Collins Andrew
Abstract excerpt
Efficient methods are available for positional cloning of major genes by linkage and linkage disequilibrium (LD). The application of these methods to complex diseases is more demanding, but advances in sequencing the human genome, SNP discovery, high-throughput genotyping techniques, LD maps, and haplotype annotation are revolutionizing positional cloning of oligogenes for common multifactorial disease.
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