Article
Tracking disease genes by reverse genetics.
Journal of psychiatric research - 1 Oct 1992
Pignatti P F, Turco A E
Abstract excerpt
Increasingly, human genes are being identified by the "reverse genetics", or "positional cloning" approach. This molecular genetic strategy is particularly useful in mental illness, for which no readily detectable functional alterations are present to indicate candidate genes. The positional cloning procedure is briefly described. Significant examples of successful positional cloning are presented, including the...
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