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Article

Positional cloning: single-gene cardiovascular disorders.

Methods in molecular medicine - 1 Jan 2006

Li Duanxiang

Abstract excerpt

Positional cloning is a comprehensive genetic strategy used to identify a disease-causing gene without any prior knowledge of the pathogenesis or protein defects involved in the disease process. The basic process involves collection of accurately diagnosed patients and their family members, genotyping DNAs with polymorphic DNA markers mapped to specific regions on chromosomes, genetic linkage analysis to...

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PMID: 17071993
DOI: 10.1385/1-59745-159-2:125

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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