[Positional cloning--current status and future directions].

Abstract excerpt

Several strategies for isolating disease genes have been developed. In functional cloning, the gene is isolated based on information on the function of gene products (proteins). In contrast, positional cloning is based on the isolation of the disease gene, starting from the knowledge of its location on the genome. The flow chart of positional cloning was described as follows; 1) identification of the location of...

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