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Article

Lovastatin downregulates renal myofibroblast function in vitro.

Nephron - 1 Aug 2002

Kelynack Kristen J, Hewitson Tim D, Martic Marina, McTaggart Steven, Becker Gavin J

Abstract excerpt

Interstitial fibrosis is recognised as the best histological predictor of progressive renal disease. Myofibroblasts contribute to this process through several functions including hyperproliferation, collagen and collagenase synthesis and reorganisation of extracellular matrix. Recent limited in vitro studies suggest that 3-hydroxy-3-methylglutaryl-coenzyme A (HMG CoA) reductase inhibitors may reduce renal injury...

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Identifiers

PMID: 12138276
DOI: 10.1159/000065034

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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