Enhancement of Saccharomyces cerevisiae end-joining efficiency by cell growth stage but not by impairment of recombination.

doi:10.1093/genetics/161.3.1015

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Article

Enhancement of Saccharomyces cerevisiae end-joining efficiency by cell growth stage but not by impairment of recombination.

Genetics - 1 Jul 2002

Karathanasis Elissa, Wilson Thomas E

Abstract excerpt

Cells can repair DNA double-strand breaks by both homologous and nonhomologous mechanisms. To explore the basis of pathway utilization, we developed both plasmid and chromosomal yeast repair assays in which breaks are created with restriction endonucleases so that nonhomologous end-joining (NHEJ) competes with the single-strand annealing (SSA) recombination pathway, which we show acts with high efficiency via...

Topics

Base Sequence
DNA Repair
Genotype
Glucose
Molecular Sequence Data
Plasmids
Recombination, Genetic
Repetitive Sequences, Nucleic Acid
Restriction Mapping
Saccharomyces cerevisiae
Sequence Deletion
Temperature

Source

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Identifiers

PMID: 12136007
DOI: 10.1093/genetics/161.3.1015
PMCID: PMC1462173

Genes

RAD52

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