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Article

Mice transgenic for the human Huntington's disease mutation have reduced sensitivity to kainic acid toxicity.

Brain research bulletin - 1 May 2000

Morton A J, Leavens W

Abstract excerpt

The mechanism underlying the pathology of Huntington's disease (HD) is unknown, although there is substantial evidence supporting a role for excitotoxicity. The discovery of abnormal aggregations of protein in the brains of patients with HD, as well as in the brains of transgenic mice modeling th...

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PMID: 10779703
DOI: 10.1016/s0361-9230(00)00238-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-10779703-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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