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Article

Early dysfunction and progressive degeneration of the subthalamic nucleus in mouse models of Huntington's disease

19 Dec 2016

Abstract excerpt

The subthalamic nucleus (STN) is an element of cortico-basal ganglia-thalamo-cortical circuitry critical for action suppression. In Huntington's disease (HD) action suppression is impaired, resembling the effects of STN lesioning or inactivation. To explore this potential linkage, the STN was studied in BAC transgenic and Q175 knock-in mouse models of HD. At <2 and 6 months of age autonomous STN activity was...

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PMID: 27995895
DOI: 10.7554/elife.21616

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