Article
Feasibility of using genetic linkage analysis to identify the genes encoding T cell-defined minor histocompatibility antigens.
Tissue antigens - 1 Apr 2002
Warren E H, Otterud B E, Linterman R W, Brickner A G, Engelhard V H, Leppert M F, Martin P J, Riddell S R
Abstract excerpt
We have evaluated the utility of genetic linkage analysis to identify genes that encode minor histocompatibility antigens using vaccinia virus vectors as a simple and convenient method for transient expression of class I MHC molecules in lymphoblastoid cell lines. As a test case, we used a CTL clone that recognizes HA-8, a minor histocompatibility antigen encoded by the KIAA0020 gene and presented by HLA-A*0201....
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