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Article

Staphylococcus aureus strains lacking D-alanine modifications of teichoic acids are highly susceptible to human neutrophil killing and are virulence attenuated in mice.

The Journal of infectious diseases - 15 Jul 2002

Collins L Vincent, Kristian Sascha A, Weidenmaier Christopher, Faigle Marion, Van Kessel Kok P M, Van Strijp Jos A G, Götz Friedrich, Neumeister Birgid, Peschel Andreas

Abstract excerpt

Staphylococcus aureus is resistant to alpha-defensins, antimicrobial peptides that play an important role in oxygen-independent killing of human neutrophils. The dlt operon mediates d-alanine incorporation into teichoic acids in the staphylococcal cell envelope and is a determinant of defensin resistance. By using S. aureus wild-type (WT) and Dlt- bacteria, the relative contributions of oxygen-dependent and...

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PMID: 12134257
DOI: 10.1086/341454

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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