Article
Staphylococcus aureus Peptide Methionine Sulfoxide Reductases Protect from Human Whole-Blood Killing.
Infection and immunity - 15 Jul 2021
Beavers William N, DuMont Ashley L, Monteith Andrew J, Maloney K Nichole, Tallman Keri A, Weiss Andy, Christian Alec H, Toste F Dean, Chang Christopher J, Porter Ned A, Torres Victor J, Skaar Eric P
Abstract excerpt
The generation of oxidative stress is a host strategy used to control Staphylococcus aureus infections. Sulfur-containing amino acids, cysteine and methionine, are particularly susceptible to oxidation because of the inherent reactivity of sulfur. Due to the constant threat of protein oxidation, many systems evolved to protect S. aureus from protein oxidation or to repair protein oxidation after it occurs. The S....
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