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Article

Alanylation of teichoic acids protects Staphylococcus aureus against Toll-like receptor 2-dependent host defense in a mouse tissue cage infection model.

The Journal of infectious diseases - 1 Aug 2003

Kristian Sascha A, Lauth Xavier, Nizet Victor, Goetz Friedrich, Neumeister Birgid, Peschel Andreas, Landmann Regine

Abstract excerpt

Staphylococcus aureus is inherently resistant to cationic antimicrobial peptides because of alanylation of cell envelope teichoic acids. To test the effect of alanylated teichoic acids on virulence and host defense mediated by Toll-like receptor 2 (TLR2), wild-type (wt) S. aureus ATCC35556 (S.a.113) and its isogenic mutant expressing unalanylated teichoic acids (dlt(-)) were compared in a tissue cage infection...

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Identifiers

PMID: 12870123
DOI: 10.1086/376533

Genes

TLR2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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