Article
Promoter sequences of varicella-zoster virus glycoprotein I targeted by cellular transactivating factors Sp1 and USF determine virulence in skin and T cells in SCIDhu mice in vivo.
Journal of virology - 1 Jan 2003
Ito Hideki, Sommer Marvin H, Zerboni Leigh, He Hongying, Boucaud Dwayne, Hay John, Ruyechan William, Arvin Ann M
Abstract excerpt
Varicella-zoster virus (VZV) glycoprotein I is dispensable in cell culture but necessary for infection of human skin and T cells in SCIDhu mice in vivo. The gI promoter contains an activating upstream sequence that binds the cellular transactivators specificity factor 1 (Sp1) and upstream stimulatory factor (USF) and an open reading frame 29 (ORF29)-responsive element (29RE), which mediates enhancement by ORF29...
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