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Article

Integrin-mediated long-term B cell retention in the splenic marginal zone.

Science (New York, N.Y.) - 19 Jul 2002

Lu Theresa T, Cyster Jason G

Abstract excerpt

The mechanisms that control localization of marginal zone (MZ) B cells are poorly understood. Here we show that MZ B cells express elevated levels of the integrins LFA-1 (alphaLbeta2) and alpha4beta1 and that they bind to the ligands ICAM-1 and VCAM-1. These ligands are expressed within the MZ in a lymphotoxin-dependent manner. Combined inhibition of LFA-1 and alpha4beta1 causes a rapid and selective release of B...

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Share to Chemokines, CXC
Share to Chemotaxis, Leukocyte
Share to Intercellular Adhesion Molecule-1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Lymphocyte Function-Associated Antigen-1

Share to Lymphotoxin-alpha

Share to Receptors, Lymphocyte Homing

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Source

Identifiers

PMID: 12130787
DOI: 10.1126/science.1071632

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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