Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Loss of heterozygosity at pseudoautosomal regions in human breast cancer and association with negative hormonal phenotype.

Cancer genetics and cytogenetics - 1 Jun 2002

Roncuzzi Laura, Brognara Irene, Cocchi Stefania, Zoli Wainer, Gasperi-Campani Anna

Abstract excerpt

To determine the possible involvement of X-linked genes in breast cancer, a group of human sporadic breast carcinomas were analyzed for loss of heterozygosity (LOH) at 12 polymorphic loci distributed along the whole chromosome X. LOH by at least one marker was observed in 14 of 46 informative cases and two regions of consistent LOH in 10 of 14 (71.4%) were identified at pseudoautosomal regions (PAR). Allelic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aneuploidy
Share to Breast Neoplasms, Male

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Carcinoma

Share to Chromosomes, Human

Share to Neoplasms, Hormone-Dependent

Share to Receptors, Estrogen

Share to Receptors, Progesterone

Share to X Chromosome

Source

Identifiers

PMID: 12127402
DOI: 10.1016/s0165-4608(01)00652-5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Loss of heterozygosity at pseudoautosomal regions in human breast cancer and association with negative hormonal phenotype.PMID 12127402Read ↗

Loss of heterozygosity on the X chromosome in human breast cancer.Semantic proximity Read ↗

Loss of heterozygosity on chromosome XP22.2-p22.13 and Xq26.1-q27.1 in human breast carcinomas.Semantic proximity Read ↗

Elevated DNA sequence diversity in the genomic region of the phosphatase PPP2R3L gene in the human pseudoautosomal region.Semantic proximity Read ↗

Loss of heterozygosity at 17p13.3-ter, distal to TP53, correlates with negative hormonal phenotype in sporadic breast cancer.Semantic proximity Read ↗

Significant allelic loss of ANX7region (10q21) in hormone receptor negative breast carcinomas.Semantic proximity Read ↗

Alterations of the 16q22.1 and 16q24.3 chromosomal loci in sporadic invasive breast carcinomas: correlation with proliferative activity, ploidy and hormonal status of the tumors.Semantic proximity Read ↗

Loss of constitutional heterozygosity on chromosome 11p in human ovarian cancer. Positive correlation with grade of differentiation.Semantic proximity Read ↗

Frequent loss of heterozygosity targeting the inactive X chromosome in melanoma.Semantic proximity Read ↗

A one centimorgan deletion unit on chromosome Xq12 is commonly lost in borderline and invasive epithelial ovarian tumors.Semantic proximity Read ↗

Allelic loss on chromosome 7q in ovarian adenocarcinomas: two critical regions and a rearrangement of the PLANH1 locus.Semantic proximity Read ↗

Deletion of the pseudoautosomal region and lack of sex-chromosome pairing at pachytene in two infertile men carrying an X;Y translocationSemantic proximity Read ↗

Allelic loss at chromosome 13q12-q13 is associated with poor prognosis in familial and sporadic breast cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.