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Article

Transgenic expression of the protein-L-isoaspartyl methyltransferase (PIMT) gene in the brain rescues mice from the fatal epilepsy of PIMT deficiency.

Journal of neuroscience research - 1 Aug 2002

Shimizu Takahiko, Ikegami Takashi, Ogawara Midori, Suzuki Yo-ichi, Takahashi Mayumi, Morio Hidenori, Shirasawa Takuji

Abstract excerpt

Protein-L-isoaspartyl methyltransfearase (PIMT) plays a physiological role in the repair of damaged proteins containing isoaspartyl residues. In previous studies, we showed that PIMT-deficient mice developed a fatal epileptic seizure associated with the accumulation of damaged proteins in the brain. The mutant mice also showed a neurodegenerative pathology in hippocampi and impaired spatial memory. Still...

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PMID: 12125075
DOI: 10.1002/jnr.10301

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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