Article
Chromosome-wide SNPs reveal an ancient origin for Plasmodium falciparum.
Nature - 18 Jul 2002
Mu Jianbing, Duan Junhui, Makova Kateryna D, Joy Deirdre A, Huynh Chuong Q, Branch Oralee H, Li Wen-Hsiung, Su Xin-Zhuan
Abstract excerpt
The Malaria's Eve hypothesis, proposing a severe recent population bottleneck (about 3,000-5,000 years ago) of the human malaria parasite Plasmodium falciparum, has prompted a debate about the origin and evolution of the parasite. The hypothesis implies that the parasite population is relatively homogeneous, favouring malaria control measures. Other studies, however, suggested an ancient origin and large...
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