Article
Recent origin of Plasmodium falciparum from a single progenitor.
Science (New York, N.Y.) - 20 Jul 2001
Volkman S K, Barry A E, Lyons E J, Nielsen K M, Thomas S M, Choi M, Thakore S S, Day K P, Wirth D F, Hartl D L
Abstract excerpt
Genetic variability of Plasmodium falciparum underlies its transmission success and thwarts efforts to control disease caused by this parasite. Genetic variation in antigenic, drug resistance, and pathogenesis determinants is abundant, consistent with an ancient origin of P. falciparum, whereas DNA variation at silent (synonymous) sites in coding sequences appears virtually absent, consistent with a recent origin...
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