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Replication failure, genome instability, and increased cancer susceptibility in mice with a point mutation in the DNA ligase I gene.

Cancer research - 15 Jul 2002

Harrison Caroline, Ketchen Ann-Marie, Redhead Nicola J, O'Sullivan Maureen J, Melton David W

Abstract excerpt

DNA ligase I has a key role in DNA replication in the joining together of short replication intermediates. We used gene targeting to introduce a point mutation into the mouse DNA ligase I gene that was present in a human cancer patient with immunodeficiency and a cellular accumulation of DNA replication intermediates. Mutant mice grew more slowly and showed hematopoietic defects at critical stages at which the...

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PMID: 12124343

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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